No I wouldn't even if my co-worker is my best friend and would tell her no. I've been burned before by lending out my stuff to people - either they break it or they refuse to return it to me even after hunting them down. This wasn't a handbag but when I doing my grad studies, I lent out a rare expensive book to my then best friend because she wanted to use it for research. After she refused to give it back to me and told me, she's keeping it because it was in her possession. We parted ways after that incident. I am still unable to track down another copy of that book. So never again - I don't trust anybody besides my sisters and mother to lend anything out that I want back in the same condition or to even get it back!
Wow ... what an unbelievable story ... I know the law says possession is 99 percent of ownership, but what a classless thing to do!
Even if I knew I'd get my bag back, I wouldn't loan one out. I've given bags away, once I'm sure I am done using them and can honestly tell myself I don't care what happens to them next ... I take good care of my stuff and know I'd be upset of I loaned something out and it got damaged or lost, even unintentionally. I think it's perfectly fine to say you don't loan out your bags, and point them to a site that rents bags out! HTH!