Yes.
If an item is accurately described, you can have a no return policy and if a buyer requests a return for anything other than "not as described," you can refuse.
If a buyer opens SNAD, you can refuse the return and argue with the buyer till the cows come home but if the buyer claimed SNAD, the seller will lose every time.
My way of handling:
I have a no return policy but I've never refused an honest buyer who lets me know she doesn't like, doesn't fit, wrong color, duplicate, etc. I will accept the return for a refund of the purchase price. (Initial shipping and return shipping are at the buyer's expense. I don't have "free" shipping so it's easier to issue a refund for just the item than if shipping was built into the price.)
In these cases, I find it's a win-win all around. I don't make the buyer keep an item she doesn't want, I get a credit for fees on the amount of the refund and other than the 30 cents fee, I'm not out anything other than a bit of time. I get the item back and can relist and resell. Buyer is happy because she didn't feel forced to lie about the condition, wasn't forced to keep something she doesn't want and doesn't have to worry about reselling it herself.
If a buyer is intent on returning and if the seller refuses or if buyer doesn't want to pay return shipping, she'll file SNAD and seller will have to pay return shipping as well as the full purchase price in a refund.