For the most part, I travel with the same handbags I use every day which are 90% designer bags and a few contemporary bags. When I travel, I want to look just as nice as when I'm home so I may pack several bags to wear. And, since I'm not traveling to high crime / terrorist areas 😳, I don't worry about the value or profile of my bag. The "riskiest" areas I travel in are major cities like New York, Las Vegas, Paris, Madrid and I don't consider those "risky" at all. I can't even get the hubster to go to relatively safe Cancun on vacation because he has concerns over kidnapping / drug crime. So, I feel comfortable dressing as I would at home.
That being said, I just bought a vintage black
Prada nylon and leather shoulder bag because it's durable, lightweight and not attention getting. I can see carrying this when I'm casual and it's rainy, on airplanes or car trips because I wouldn't care where it landed.
Last note, when I travel on planes for leisure, I carry a back pack through security with my handbag of the day inside. So when I put a bag under the seat it's the backpack, my handbag doesn't have to touch the ground. My other option (business travel) is a roomy vintage
Coach leather tote which has seen a million miles & looks the same as the day I bought it. I couldn't care less about that bag being on the floor of the plane. That's the one reason I haven't upgraded it. I don't want to buy a $2500 tote I care about and have to baby.