I gave it a shot already. She had a long bath, first scrubbed with Dawn. The darker spots I then covered in oxy something whatever spray (max out?) and left for 30 minutes. Then I rinsed that. Seemed like the darker spots were fading a bit so I did that again. Then I scrubbed it all over the twill with fels naptha laundry soap. Not great for leather but fine for twill I think. Then a vinegar rinse. I think it looks cleaner and more evenly colored and the spots that are still there are at least lighter. I hope! At least worst case scenario in which the leather bleeds on the twill didn't happen. The handles do feel pretty soft so if I attempt anything more with her I'll be covering those from now on. It's always hard to tell for sure when its drying but I think it's overall better.
All the other bags washed and drying, no issues. And for now my day is done