opinions needed...please!!!

Mono Noe! I think it would be easier to get into it.

My hair stylist just sold her large Musette because she didn't like having to pull up the flap and said it was awkward to get things in and out of it.
 
Hmmm...that's kinda hard because I like both, and I think they're both completely different. Noe would be a good carryon bag but Musette would be a good bag for sightseeing...

Even though the Musette is more streamlined, I think both can hold plenty, but the Noe would give you more leeway...and may be easier to get in and out of since it's not a flap bag.