Hmmm...that's kinda hard because I like both, and I think they're both completely different. Noe would be a good carryon bag but Musette would be a good bag for sightseeing...
Even though the Musette is more streamlined, I think both can hold plenty, but the Noe would give you more leeway...and may be easier to get in and out of since it's not a flap bag.