Sorry, djfmn, I have an Alexia Midi but I only received it not too long ago, and have only used it once (it's a weekend bag for me), so I don't really have much of a sense of the zipper opening giving me any issue. The time I did use it, I didn't find the zipper opening to be too small or narrow or anything, as I believe I was still able to get in and out of it easily enough -- was that the problem you've seen posts on?
I remember the other issue being mentioned of how the zipper pulls can sometimes "fall" into the tiny gap at the ends, because of the excess zipper tape that is tucked into the bag. I don't find this to be too much of an issue, though, as I'm usually able to zip the bag closed again easily enough, if I tug on the end of the excess zipper tape from inside the bag. (My Penelope Messengers that have the zipper added to the centre compartment are similarly constructed, so I've gotten used to this zipper issue from this style.)
Overall, I do think my Alexia Midi can be quite functional and good to use, even though I've not actually used it much yet. I may even switch one of the items in my final order to another Alexia Midi instead of a triple-zip Penelope Messenger (although I'm waiting to hear back from Marco on his views about the leather/style combination I have in mind).
In terms of Little Muse vs. Alexia Midi, the other key differentiator to me is the zipper closure that Alexia Midi has -- although I enjoy my Little Muse, I generally prefer bag styles with a zipper closure for better security, so Alexia Midi is something I think I'd use in more situations than Little Muse. This is totally a preference issue, though!
Hope this helps!