I totally agree with the other posts ... you can have another reception in your hometown so your relatives can attend, including your grandparents. Just think how happy everyone will be!
I went through the same thing. I got married in CA and most of my relatives are on the east coast. Many friends of the family who I would have loved to have at my wedding were unable to attend. But ... these things are just part of life.
I would HIGHLY recommend that you hire a videographer, so that you can send a copy of your wedding to people that were unable to attend like your grandparents. I'm sure they would truly appreciate it!