DE is great for stain-free, all-weather use and it's relatively lightweight. I agree that if you're going to a place where you might encounter pickpockets and/or robbers if would be better to carry something more discreet. Some people bring foldable totes to toss their fancier bags in when they go to such places but you'll probably won't have the space to carry one of those in a 25.
Oh I love Bal bags & the Town is beautiful!
But a huge benefit to the Speedy B is that you can also take off the strap & wear it as a "normal" Speedy if you want the option to wear it differently
Agreed about nylon bags for travel: I use a fairly lightweight turquoise Tumi cross-body bag with a slim profile. I've had it for 10 years, used it on every domestic and international trip and also around town at home, and it looks as good as new. It's indestructible, rain-proof, easy to clean, with good organization. I'm not as fond of the current Tumi bags...but think any well-made nylon bag is your best investment for travel.
I mostly travel in the US so I should be fine (hopefully ).
Another option -- the BV intrecciato napa crossbody. Lightweight, with a zipper for security, and slim profile. I carried mine all over Europe last year:
http://forum.purseblog.com/showpost.php?p=25481464
Sorry I've been absent for ages. Honestly, the Tumi doesn't seem to pick up much dirt. I've spot washed it with soap and water. After finding what looked like grease on it recently, I took a chance and threw it in the washing machine, leather strap and all. Came out looking great.I love the Tumi for travel, too! how do you clean yours?