I started Retin-A in July at the lowest .25 and had no reaction. I shower and wash my face after dinner and then apply the Retin-A before bed. My dermatologist suggested waiting an hour after washing my face before applying it. Since I had no reaction on my face or neck, I started using it on my décolleté area as well. I upped it to .5 after 3 weeks and have been using that since. Some minor flaking, specifically around the nose, but no where else. My skin looks fantastic. I'm turning 42 next month, and have fair skin and stay out of the sun, but the fine lines had started, specifically under my eyes and the nasal folds. The lines around my eyes are shallower and my skin feels tighter every where. I'm planning on going to the full 1.0 strength next month. I don't need foundation anymore. I put sunscreen on, let it soak in and use pressed powder and my skin looks even, without the splotchy redness I had before beginning Retin-A. I'm shocked at how well it's worked. My pores are smaller, and there's a general glow that even my husband noticed. I don't put anything over or under the Retin-A and haven't had dry issues at all, oiliness or breakouts. Prior to using it my skin had redness issues, enlarged pores, and severe dryness. It's a wonder product, IMO. I wish I'd started it 10 years ago. (My prescription is for the Obagi Tretinoin)