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^ Aren't Grysons starting to run into the $600 - 700 range? I was browsing NM one day and it actually stuck out to me that they WERE quite expensive for what they are...I bought a Gucci canvas bag as a gift for my MIL last September and it was around $650. So I actually thought "wow, Grysons cost the same as some higher end brands now".
Depends on what you mean by "designer", and what your price range is. As for some lesser known/carried brands that I think you get a lot of "bang for your buck" from, I like Gryson, Botkier, just got an Olivia Harris (arrives tomorrow!), Linea Pelle, Cole Haan... they have great quality leathers and bags that are wonderful without breaking the bank. I am always amazing that I can get a buttery leather, suede-lined Gryson on sale for a fraction of the cost of a canvas Gucci.
So are you looking for a leather tote bag or purse?