I am not sure if i have weak shoulders or am just a weinee...but i have the mm and after a day of shopping with the hubby and 2 year old (and all of their junk) my shoulder was hurting...but that seems to happen with any bag other than my marc jacobs mercer mp. I think because it has one large padded strap. So if you don't have that problem as a whole, I don't think you will have any problems at all with the neverfull. It is a great bag!