End of the day, no one buys jewelry with resale value in mind. We buy jewelry because it's pretty and we like it. How anyone decides what they wish to pay for "pretty" is a personal and financial choice.
I have enough jewelry to open my own jewelry boutique. I have natural diamonds, natural rubies, natural stones of all colors. I also have lab-grown diamonds, other lab-grown stones, cubic zirconia, and Moissanite jewelry. I love them all with no distinction of whether they came out of the ground or a laboratory. No matter to me. If anyone were to ever ask, if [whatever] is "real" then they get the following reply: "Can you see it?" The person says, "Yes, of course." Then I say, "So then it's real." That's all any RUDE person who would ask that question deserves.
Yes, I walk a different path and proud of it.