+1 for backpack (especially if you have a big clunky laptop) but my Neverfull handles a Macbook OK too and I do that sometimes. I like Tumi backpacks. I put a photo of my model below, which they don't sell anymore but it's along the same lines as the links at bottom. The Saffiano-ish leather is very light and durable, plus it has a handle strap in the back that makes traveling super convenient. I use it sometimes on vacation even, since they all come with a lock.

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Shopbop Designers - Fashion Designer Category Index
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Shopbop Designers - Fashion Designer Category Index
Shopbop offers assortments from over 400 clothing, shoe, and accessory designers. Shop your style at Shopbop.com!