I think guys will look cool with Rocco, Mulberry Oversized Alexa, Proenza Schouler Large PS1, Celine Tote, Givenchy Nightingale, Loewe Amazona, Ralph Lauren Ricky, Birkin HAC.
Unisex bags like Hermes Jypsiere n Halzan?
Hmm....What about LV Alma GM but in Epi or DE, Phillip Lim Large Pashli?
I think most bags with big studs or big zip will probably look good on man because they are rugged/edgy looking. So are big doctor bags, big saddle or big bucket (Ralph Lauren bucket!)