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I'm not sure if you are referring to just the designers but IMO the top 5 designer bags or must haves would be the classic from each designer which is timeless and hold it's value well.
1) Hermes Birkin
2) Hermes Kelly
3) Chanel 2.55 reissue
4) Bottega Veneta Cabat
5) This is a tough one but if you like Balenciaga then the motorcycle bags, for LV the speedy etc I'm sure you get my drift.