That's true, and it's important not to lose perspective about what really matters. But I think small things can sometimes be an indicator of a much bigger picture, as the OP described in the start of this thread. The events you described are all so devastating that of course they're life-changing, but some positive events also have huge impacts (getting married, having kids, winning the lottery). And while the life-changing events you describe are horrible in part because there's nothing anyone could do to prevent them, a lot of life-changing decisions begin with a choice (starting a new job, breaking up, moving across the country, etc).
Sometimes those choices are triggered by small things. For example, people sometimes end relationships over really insignificant issues, but generally it's because it's one thing that makes them realize their goals/communication styles/expectations/etc. are ultimately incompatible. So I guess the question is "Was there ever a time your purse triggered a life-changing event?" And I think there are definitely people who could say yes.