i guess it depends on your personality & dress style.
i personally go for damier, i left the colourful bags decision left to my balenciaga or multicolore line
Thought both are very nice, I would choose the Red Epi Speedy because (1) it will not sag as much and (2) epi leather is very durable & interesting looking especially in colors and (3) the RED color in the Epi is eye popping gorgeous!Please let us know what you decide.
Going against the grain here - I would go with the Damier Speedy. I love the chocolate leather. The red would really limit what outfits I would wear it with.
I say get a red epi with titanium hardware. I have one and I LOVE it! I use it quite often. It can be dressed up or down. It's a fabulous bag that doesn't need to be babied, KWIM?