Okay, not to be stupid or judgmental, but it really depends on your body size (i.e. do you have fat arms)?
My best friend (skinny as a stick) wears the bag with no problem. Plenty of room in the straps and it doesn't dig on her arms. However, she doesn't keep much in her purses either.
I am what you kindly call "a plus size girl". I have to be very careful about straps because they often do dig in my arms, although sometimes it is the large amount of crap (computers in particular) I put in the purses. I am assuming you want one of the larger totes with larger straps (I have the latest scarf in green with longer thin straps and I can wear it with all my junk but on a comfort level from 1to10 only a 6), I think the straps on the patchwork gallery tote are a little uncomfortable, but again I have big arms, stick lots of stuff in the purse, and is that one even suppose to go on your shoulder???
I highly recommend you try one on at a local store just to see if you are comfortable. Also feel free to stick ALL your stuff in the display and walk around the store a couple of times. If you are okay then, likely you will still be okay with prolonged use.
Other note, try it on with a winter coat if you wear one regularly. I have several bags that have to be benched for winter because the straps do not fit over my coat.
If you are looking at one in particular I could go try it on tomorrow and let you know what I think (if you care).