depends on the type of leather!
this is the only way i know how to explain it.
i have the polka dot gallery tote. wear it with all my clothes, including my fave pair of denim jeans (i have two of the exact wash in this style) and the colors don't rub off. the bag has been kept up pretty well to and i ride the bus!
the legacy bags, which is not made with regular ol' leather that polka dot is made of, that one i have to be careful, the jeans will rub off and the leather, this one vegatable oil tanned vachetta *i get a lot of different, info, from managers as well as TOT* will absorb it.
if the leather can be cleaned and moisturized like the polka dot, you'll be fine.
if it cannot, i would be cautious. truly. with white, like suede, is not meant for an everyday bag.
only people who are obessed with white, like me, who wear it everyday