It totally depends on the style.. I guess I just don't like it when leopard print tries to look serious. When it's fun (ie. Marc Jacobs) I kind of like it.
I love the leopard print lining in my Dolce and Gabbana satchel, but I wouldn't want a whole leopard-print bag. Unless it was just some casual thing for the beach or whatever. Wouldn't be an everyday choice.
Every closet should have something leopard, whether handbags or accessories. I agree that it depends on the style and the fabric. Leopard can either go really wrong or it can be amazing.
I don't really like leopard-print anything, BUT as far as it goes I'm warming to the Mulberry smudged putty leopard print (or 'smutty' print as I like to call it)