Good topic. It depends where Im going. If its a vacation where Ill be going to fancy restaurants and places (such as las vegas), then I like to carry my vernis alma pm.
If Im going to a hot humid place where Ill be doing lots of walking (such as Asia) or somewhere where it rains a lot (such as Vancouver), then I like to bring my Damier speedy because the vachetta will not oxidize and it is lightweight.
The Neverfull GM is good for an overnight trip but I wouldnt use it in a crowded city since it has no zipper and warrants pit pocketers.