Retain - A is the way to go. It is a prescription medicine. It is one of the few things proven to help wrinkles and fine lines. In talking to more than 1 dermatologist - all have said that it doesn't matter which cream/serum you buy in the store. They are all basically the same. You need Retain A to make a difference. The differences are basically (in the over the counter products) packaging, advertising and name recognition. None of the over the counter products have any ingredients in them can make a real difference.
Here is a good site with reviews of products and ingredients. It is free to sign up if you want to get her newsletters.
http://www.cosmeticscop.com/learn-paulas-choice.aspx