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If this were pink or floral or Pastel, no one would even ask this question. If this were a kid's backpack with Disney princesses all over it, the same. Yes, either bag can be worn by anyone! Nearly all my LV is from Men's and no one even knows or cares.
I actually think this looks fantastic on a female, have never seen in person or tried it, but that buckle flap is so classy and looks like traditional "female " flap handbags- like Coach styles etc for women- I can't think of better descriptions right now but hopefully you get what I mean. If this were in all brown (non branded) leather, it's like a classic saddle bag, does that make more sense.