49 sq mi is not made in SF. They're made in China but are very nice quality wise.
Their showroom is open weekdays and is in South SF closer to the airport.
http://www.sfmade.org/ lists companies that make things in SF. I can't think of bagmakers offhand besides Rickshaw bags and certain timbuk2 models but both are nylon messenger bag styles. Most of the made in SF stuff I can think of is casual and messegery -not the usual tpf stuff. Hopefully someone else can chime in with either a brand or a good boutique for locally made items.