I have been told yes by a coach employee
Hope this helps!
I could be wrong, but I think I read a post in the past couple of weeks where someone used a non-alcohol wipe & it ruined their bag. I'll try doing a search...
I just use a wet washcloth & it gets everything off my HS bags from dirt to denim transfer.
ETA: Here's the thread ~ http://forum.purseblog.com/coach/heritage-stripe-tote-problem-339602.html