I use a LV Cles with my car key hanging outside, the keys I use less often, inside.
I found a Bottega Veneta key holder that attaches to the zipper on my bag and on the other end is a quick opening clip that holds my keys in the bag. I just pull the leather strap and out come the keys. Unfortunately I don't see it in their latest catalog or online. Maybe they discontinued it. It's the handiest thing.