There are facial exercises you can do. It sounds loony, but they work. Basically, they involve holding your facial muscles a certain way (you can use your fingers to help) for a few seconds. I think there's a book about it, but I learned it on ricky lake back in the 90s.
Also, the more fat on your face the younger you look - which is why some people get fat from their butt injected into their face, um eeeew). To some extent it may be genetic - the slightly fattier people tend to get less wrinkles, even in their olden years.
And yes, when you apply moisturizer, apply in an upward motion.
My mother says that the more relaxed you are in your daily life, the less wrinkles you get. I am a strong believer in facials and massages for this reason, also yoga.
I personally think that if your facial muscles get held in any position for too long, you develop wrinkles where the skin creases, so when I'm meditating, I concentrate on relaxing my facial muscles in between breaths.