Our 50 was purchased resale. We have carried on (upper compartment and floor), gate checked and full checked. We do remove the strap to check. Most recently, I was on a delayed flight where the airline sent some luggage ahead on the earlier scheduled flight. The gentleman at baggage assistance did put the keepall with him in the locked office. He thought it looked too enticing and easy to grab in the roped off area in front of office.
My sister has a 45 or 50 she bought retail. I know she has had to check and gate check her wheeled LV carry on, but I don’t think she has ever checked the keepall. She recently had vachetta replaced after spilling something on it several years ago. I don’t remember all the details, but the spill happened in her position and had nothing to do with an airline.