Yes, absolutely. As Mandy said, the luggage tags are removable, if you don't like them. Or, you could add more charms, depending on your taste. As it happens, the seller is a great one and the price is nice.
Unless you are a feminine gay man, or a straight man who is extremely secure with his sexuality and masculinity, I would suggest that you not get the bag. I don't think the bag is unisex at all, but it's really up to what you're comfortable wearing.
I think Cheri is a little too small proportion wise for a man. A French Tote may be better. I think the patent & stripes combo is cool on a man tho! & those luggage tags can be removed. I removed mine coz it adds too much weight. Mine was tri-colour & the brown leather throughout the bag is just too heavy for me.