I took my UV Duffle out for the first time last Friday and it started to rain as I was walking across the mall parking lot. I am a chronic over-conditioner and due to the fact that I had conditioned the bag before carrying, the water didn't leave any spots, it beaded up and I wiped it off. So I think one key is conditioning or protecting the bag beforehand.......but hopefully it will dry with no damage and if not, a little conditioner couldn't hurt.