I usually lock them up in my luggage and lock it in the closet and take the keys with me. I always worried about these things also. Also keep the do not disturb sign on your doors at all times.
I would lock my nice stuff in my suitcase. I travelled enough before to realized that even if ppl don't steal my stuff they might just play around with your stuff. I don't want anyone touching my birkin and scratch it up.
I lock up my tooth brush too just incase the maids might use it to clean or put it in the toilet bowl if they want to be nasty.
I lock up my tooth brush also!!!!!
I don't know if anyone else has a problem with this, but when I travel with more than one bag, I'm afraid of leaving an expensive bag in my room. The safe is always too small. It seems like a hassle to lock luggage and anyone can remove those anyway. I've never had a problem in the U.S. but twice I had things taken (by the maids?) in Mexico--an Hermes scarf and New La Perla lingerie. What do you do with your valuables in hotels?
I would lock my nice stuff in my suitcase. I travelled enough before to realized that even if ppl don't steal my stuff they might just play around with your stuff. I don't want anyone touching my birkin and scratch it up.
I would also use the safe. and if the item is too large, lock the suitcase.
I was surprised the last time I traveled, my 28cm kelly actually fit in the safe very well w/ plenty of room for other things!
Best is not to bring it if you are that worried.