I say it depends... The St Louis canvas becomes supple more quickly than the Monogram canvas (@least mine did). Although the Neverfull comes with a pocket on the inside, the St Louis comes with the removable wallet, which is a good size (lipstick, women hygiene products, pens/pencils, etc). The handles are quite different in thickness, with the St Louis having a much thicker handle (there's a posting somewhere on the forum with a comparison of the two that may help in your decision). For me, I say the Goyard St Louis tote. It's much less common, and I love the slouchy-ness of the bag after using it just a few times. Hope this helps!