I always start the opening bid at the amount I am MOST willing to sell the item for. Therefore, if I want to recoup what I've paid, then that is the amount that I start with.
I don't bother with RESERVES anymore ... why? Because they are a pain-in-the-
, and you will get inundated with questions asking you "
How much is the Reserve ...", bla bla bla. Personally, I feel that starting an auction low and having a high Reserve only leads people to believe that you are willing to part with the bag for the low amount (trust me - I've been eBaying for many years; I'm always astounded by how many folks have absolutely NO CLUE as to how auctions work - both live & online!!!). Then if, heaven forbid, the Reserve isn't met, you will get inundated again with inquiries "oh well ... can I buy it for what I bid?" which, if really low, is absolutely ridiculous! I've had some people get REALLY nasty because they honestly thought that they would get a high-end item for $500 ... please?!!?
I don't bother with "offers" either because, again, because you will get inundated with really low-ball offers (especially from dealers, who will just turn that sucker around for significantly more!).
Sorry to sound so negative, but I've found that it's best to just put up the item for what you want and take your chances. If it doesn't sell, then you go down slowly ... why should you lose your shirt ... unless, of course, you need to sell it quickly because you really need the $$$.