I certainly try to avoid it if possible, but I do from time-to-time. I know it's a sin , but I try to purchase bags with a potential to clean up nicely. I have professional leather and cloth cleaner too. I am also no where near a germaphobe (I have a medical/science background and I think regular exposure to germs will keep my immune system working properly . I have been thinking about purchasing a hook though. It makes sense since I want to keep my handbags looking nice for as long as possible.