i also think it depends on your skin type. I personally use the Clinique oil-free gel moisturizer and the #2 clarifying lotion, but use Cetaphil to cleanse (less drying). However, my friend who used to have very bad acne found that La Mer really really helped her, and it's true, you can see a real difference with her skin. Also keep in mind that there's different lines for every brand to go with your skin type, so you might have to "play around" 'til you find the right one!