I've had mine since January (RG, new screw system) and my screws are still tight, no loosening at all. I've had to take it off twice, once for engraving and once for a medical thing and when I've screwed it back on both times the screws haven't moved. I do screw it on very tight though, putting a lot of pressure on the screws. I would not use Loc-tite, no way!