The Epi is a rigid leather so is susceptable to wrinkles. In my epi blue speedy 25, i have a crease in the middle of one side of the bag at the bottom, as that's where it has been pushed in as the bag was not full.
The Epi is not as hardy as the mono or damier as you can squash those without worrying about creasing or wrinkles. I don't have wrinkles near the zipper of my epi so i guess you will need to look at each epi piece individually to check out the creases/wrinkles.
If it's your first speedy, i'll get the mono as it's timeless and a classic (and if you don't like the patina, then get the damier which is what i did)