I did spray mine with Collonil Nanopro prior to using it, just because I found after handling it, it seemed to attract dirt and makeup. After spraying the bag, it was much easier to wipe off any stains that it did attract. I think it depends on how worried you are about the bag staining, and what color it is. Mine is a darker color, but for some reason, any makeup or dirt marks still show up very strongly on it.