Man-Made Material!

Recently purchased a Fossil Sydney tote made out of cow-hide trim and man-made material. Does anyone have more information about the man-made material they use? If it's PVC, do you consider it safe? I was hoping it was coasted canvas (made with less PVC, but I don't believe it is). I have always purchased genuine leather handbags. But this purse was adorable. Whenever I read man-made material I always think the worst. I know back in 2010, CEH investigated top retailors and found a crazy amount of lead in handbags.
 
I am stuck with a pair of cole haan sandals which were sold to me at the cole haan outlet as " leather" and cole haan website described them as " synthetic leather". What are they smoking???