In addition to the usual wallet, makeup bag, pen (in makeup bag), tissues, iphone, keys, sunnies, I have:
lipglosses/lotions in zip loc bag and an extra zip loc (I fly a lot for work and no way are those evil security people getting my lipglosses because they're not in the stupid little plastic bag
Jawbone bluetooth headset (in an HH cp)
Emergency power thingee for my iPhone (in another HH cp) - also has flash drive in same cp
Often my Kindle is in my bag - you never know when you'll have some down time and I fly a lot - if not, I'll have a magazine stuffed in there
Agenda (for taking notes in meetings only - use phone for contacts)
Biz Card Case (HH Sophie)
Sometimes I have my 3G card in there too - usually when I'm not carrying my laptop bag
Same for my netbook - will take that if I don't want to carry laptop bag - it's so tiny it fits in most of my handbags