Should be an interesting article! How about indie designers like Melanie Dizon, Carrie Valentine and Lesa Wallace? As usual, I've just been READING about them, can't say anything about seeing their bags in real life.
http://www.lesawallace.com/
http://www.melaniedizon.com/
http://www.carrievalentine.com/
Oh, and the Magnes Sisters ... read about most of these designers elsewhere.
http://www.magnessisters.com/
Can't remember if Kale handbags was mentioned.
http://www.kalehandbags.com/flashSite/